Major NPWT

“Minus™ Negative Pressure Wound Therapy System:

A “ Revolutionary” Device Offering Better Results

  • Creating a Sub-atmospheric Pressure with Vacuum Source
  • Maintaining Wound Temperature and Moisture
  • Wound Infection and Inflammation

Minus™ Negative Pressure Wound Therapy system orchestrate the wound healing process, Cleaning of wound bed, stabilize the wound bed temperature at optimum, washing the wound bed with a dwelling time to reach dead corners of the wound bed.

Mechanism of Action

Negative pressure interacts at distinct levels with the wound environment. It works on both the lesion's macrostructure and microstructure and combines all these effects into one complicated operation that facilitates wound healing in all wound growth phases. At the macro level, NPWT extracts secretions and fluids from the lesion, decreases periwound edema, increases local blood flow and reduces ulcer size and the possibility of external sources of wound infection.1 The stimulation that the negative pressure exerts on the cell surfaces and on many of the cellular elements present in the lesion induces positive changes in both the shape and function of the cells at the micro level. NPWT has been shown to promote angiogenesis, fibrogenesis and the macrophages and leukocytes activity.2 A number of NPWT studies have been conducted in virtually all clinical conditions related to wounds and wound management, acute and chronic, from heart surgery to diabetic feet and venous leg ulcers to pressure ulcers. For most of the conditions under which it was tested, its activity has been confirmed.3-6 An interesting choice with NPWT is that it can be integrated into an antiseptic application. This occurs when antiseptics have entered the system to regularly flush wound areas (as was the case with osteomyelitis) or when they are absorbed into the material used to fill the lesion, this occurs. An antimicrobial effect to the indirect debridement of NPWT is added, as the newer antiseptics have a better efficacy and safety profile and have been tested successfully under a range of conditions.

1. Creating a Sub-atmospheric Pressure with Vacuum Source

The film has an opening where a tube is attached. The tube leads to a vacuum pump and a canister where fluids are collected. The vacuum pump can be set to run or to start and stop intermittently using its modes. The vacuum pump removes fluid and infection from the wound. The edges of the wound bring together with the help of vacuum. It also helps the wound heal by promoting the growth of new tissue. When necessary, antibiotics and saline can be introduced into the wound.

2. Maintaining Wound Temperature and Moisture

The healing stops when the temperature drops. Additionally, cooled tissues cause vasoconstriction and increase the need for oxygen from hemoglobin. As a result, to fight any possible infection there is less oxygen available for the type of white blood cells called neutrophils. Once the wound tissues cool down, such as when they are left in the open air during a dressing change, it can take up to 4 hours for the wound base to return to normal healing temperature. If a doctor changes a TID dressing, the wound may be outside the optimal healing range 50% of the time. The Minus ™ Negative Pressure Wound Therapy System delivers a heat-conditioned oxygen-rich solution to the wound bed at predetermined intervals. Therefore, as the temperature is kept at an optimum level of healing at 38 °C, the loss of temperature is eliminated. In addition, the solution will not only help to wash the wound bed to the desired temperature and continue to penetrate the dead corners of the wound edges, it will also help maintain moisture without macerating the tissue perimeters.8

3. Wound Infection and Inflammation

The wound cannot heal in the presence of debris, necrotic tissue, and infection. In addition to effectively removing debris and necrotic tissue, a solution to the infection should be provided. The mechanical removal of infections on the wound surface is important up to a point. In general, however, dead wound corners cannot be treated. The Minus ™ Negative Pressure Wound Therapy System also uses an oxygen-rich solution to fight surface-level and dead-corner infections using the dwelling function. It allows user to set dwelling time depending on the solution they deliver to wound bed in case they do not want to use oxygenated solutions.


MINUS™ Negative Pressure Wound Therapy System is a non-pharmacological method for the patients who would benefit from a suction device. It is intended to use to physically promote wound healing by means of removal of fluids, including irrigation, and body fluids wound exudates and infectious materials. The patients with the following wounds are indicated: Acute Wounds, Chronic Wounds Pressure Ulcers, Diabetic Foot Ulcers, Venous Leg ulcers, Traumatic wounds, Dehisced wounds, Partial thickness burns, Flaps, and grafts. No Studies are done on the use of Minus™ NPWT System on pregnant and pediatric patients. To use the device on such patients is at surgeons’ own disposal. Patient size and age should be considered when prescribing the device. The Minus™ Negative Pressure Wound Therapy System is intended for use in acute and chronic wounds at continual, intermittent and variable mode of settings.